Rare Variants in 48 Genes Account for 42% of Cases of Epilepsy With or Without Neurodevelopmental Delay in 246 Pediatric Patients

In order to characterize the genetic architecture of epilepsy in a pediatric population from the Iberian Peninsula (including the Canary Islands), we conducted targeted exome sequencing of 246 patients with infantile-onset seizures with or without neurodevelopmental delay.We detected 107 variants in 48 different genes, which were implicated in neur

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What practice can learn from theory: The potential impact of disposition decision factors on organisational performance

Background: Effective disposition decisions can lead to a number of value-adding benefits including economic, environmental and marketing benefits.Despite this, many organisations are not aware of the importance of disposition decisions and the impact they can have on organisational performance.Objectives: The aim of this study was to demonstrate t

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